(-)-Trans-Δ9-tetrahydrocannabiphorol

(-)-Trans-Δ9-tetrahydrocannabinol (Δ9-THC) is the main compound responsible for the intoxicant activity of Cannabis sativa L. The length of the side alkyl chain influences the biological activity of this cannabinoid. In particular, synthetic analogues of Δ9-THC with a longer side chain have shown cannabimimetic properties far higher than Δ9-THC itself. In the attempt to define the phytocannabinoids profile that characterizes a medicinal cannabis variety, a new phytocannabinoid with the same structure of Δ9-THC but with a seven-term alkyl side chain was identified. The natural compound was isolated and fully characterized and its stereochemical configuration was assigned by match with the same compound obtained by a stereoselective synthesis. This new phytocannabinoid has been called (-)-trans-Δ9-tetrahydrocannabiphorol (Δ9-THCP). It is believed that the increased length of the alkyl chain, allows THCP to have increased bonding to cannabinoid receptors such as CB1 in the brain. THCP has the impressive ability to bind to CB1 receptors in the brain 33 times more than Delta-9 THC. According to users of THCP, the high is 10 times more potent than your average THC.