Δ9-tetrahydrocannabivarin (Δ9-THCV) is a naturally occurring cannabinoid found in cannabis plants. It is a structural analog of THC (delta-9-tetrahydrocannabinol) with some distinct differences in its chemical structure and pharmacological effects. In terms of chemical structure Δ9-THCV is closely related to THC, but it has a propyl side chain instead of a pentyl side chain.

Pharmacologically, Δ9-THCV exhibits a biphasic effect, which means it can produce different effects at different doses. At low doses, it may act as a CB1 receptor antagonist, potentially reducing some of the psychoactive effects of THC. At higher doses, it can act as a CB1 receptor agonist, producing psychoactive effects similar to THC. One of the notable characteristics of Δ9-THCV is its potential to suppress appetite. Some studies have suggested that Δ9-THCV may be helpful in reducing food intake and promoting weight loss, making it of interest in the management of obesity and related metabolic disorders.

Δ9-THCV is one of the minor constituents in cannabis, typically found in lower concentrations compared to THC and CBD (cannabidiol). Its presence can vary among different cannabis strains.