Pulegone is a naturally occurring monocyclic monoterpene ketone found in various plant sources, including pennyroyal, peppermint, and rosemary. It has a distinct minty, camphor-like aroma and flavor. From a chemical perspective, pulegone is a ketone with a molecular structure composed of ten carbon atoms. It contains a six-membered ring and a carbonyl group, which contribute to its aromatic and reactivity characteristics. Pharmacologically, pulegone exhibits several potential therapeutic properties. It displays analgesic and anti-inflammatory effects, suggesting potential benefits in pain management and reducing inflammation. Pulegone also possesses insecticidal properties and has been used as a natural insect repellent. Regarding its relationship with cannabinoids, pulegone does not directly interact with the endocannabinoid system (ECS) like cannabinoids do. However, it is found in cannabis plants and contributes to the overall terpene profile. Terpenes, including pulegone, along with cannabinoids, contribute to the complex aroma and potential therapeutic effects associated with different cannabis strains. It is important to note that pulegone, when consumed in high amounts, has been associated with potential hepatotoxicity and carcinogenicity. Therefore, caution should be exercised when using pulegone or products containing high concentrations of pulegone.