[{"data":1,"prerenderedAt":23},["ShallowReactive",2],{"notifications-general-cs":3,"compound-CAROO-cs":4},"Z důvodu letních prázdnin bude laboratoř od 22. července do 9 srpna 2026 fungovat v upraveném režimu. Výsledky analýz budou k dispozici 7 až 10 dní po obdržení vzorku. Děkujeme za pochopení.",{"name":5,"shortname":6,"synonyms":7,"cas":8,"molMass":9,"pubchemLink":10,"structure":11,"important":12,"synthetic":13,"compoundClass":14,"asociationImage":17,"summarySet":18,"compoundEffectSet":22},"Caryophyllene oxide","CAROO","beta-Caryophyllene epoxide, (-)-Caryophyllene oxide","1139-30-6",220.35,"https:\u002F\u002Fpubchem.ncbi.nlm.nih.gov\u002Fcompound\u002FCaryophyllene-oxide","science\u002Fstructures\u002Fbeta-caryophyllene_oxide.png",true,false,{"id":15,"description":16},"1","Terpenoids","",[19],{"summaryText":20,"language":21},"\u003Cp>\u003Cem style=\"box-sizing: inherit; font-family: Cambria, "Cambria Math", stixgeneral, "Times New Roman", Times, serif; font-size: 20px;\">\u003Cspan style=\"font-size: 14px; font-family: "Times New Roman";\">β\u003C\u002Fspan>\u003C\u002Fem>\u003Cspan style=\"font-family: "Times New Roman"; font-size: 14px;\">‐caryophyllene oxide (BCPO) is an oxidation derivate of the more known sesquiterpene called \u003C\u002Fspan>\u003Cem style=\"box-sizing: inherit; font-family: Cambria, "Cambria Math", stixgeneral, "Times New Roman", Times, serif; font-size: 20px;\">\u003Cspan style=\"font-size: 14px; font-family: "Times New Roman";\">β\u003C\u002Fspan>\u003C\u002Fem>\u003Cspan style=\"font-family: "Times New Roman"; font-size: 14px;\">‐caryophyllene (BCP). both compounds are\u003C\u002Fspan>\u003Cspan style=\"font-family: "Times New Roman";\"> notable for having a \u003C\u002Fspan>\u003Cspan style=\"background: none rgb(255, 255, 255); font-family: "Times New Roman";\">cyclobutane\u003C\u002Fspan>\u003Cspan style=\"font-family: "Times New Roman";\"> ring, as well as a \u003C\u002Fspan>\u003Ci style=\"font-family: sans-serif;\">\u003Cspan style=\"font-family: "Times New Roman";\">trans\u003C\u002Fspan>\u003C\u002Fi>\u003Cspan style=\"font-family: "Times New Roman";\">-double bond in a 9-membered ring, both rarities in nature.\u003C\u002Fspan>\u003Cspan style=\"color: rgb(32, 33, 34); font-family: sans-serif;\"> \u003C\u002Fspan>\u003Cspan style=\"font-family: "Times New Roman";\">BCPO has a strong wooden odor and is used as cosmetic and food additive.\u003C\u002Fspan>\u003Cspan style=\"font-family: "Times New Roman";\"> \u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"box-sizing: inherit; font-family: "Times New Roman";\">BCP\u003C\u002Fspan>\u003Cspan style=\"font-family: "Times New Roman";\"> is a phytocannabinoid with strong affinity to cannabinoid receptor type 2 (\u003C\u002Fspan>\u003Cspan style=\"box-sizing: inherit; font-family: "Times New Roman";\">CB\u003C\u002Fspan>\u003Cspan style=\"font-family: "Times New Roman";\"> \u003C\u002Fspan>\u003Cspan style=\"box-sizing: inherit; line-height: 0; position: relative; vertical-align: baseline; bottom: -0.25em; font-family: "Times New Roman";\">2\u003C\u002Fspan>\u003Cspan style=\"font-family: "Times New Roman";\">), but not cannabinoid receptor type 1 (\u003C\u002Fspan>\u003Cspan style=\"box-sizing: inherit; font-family: "Times New Roman";\">CB\u003C\u002Fspan>\u003Cspan style=\"font-family: "Times New Roman";\"> \u003C\u002Fspan>\u003Cspan style=\"box-sizing: inherit; line-height: 0; position: relative; vertical-align: baseline; bottom: -0.25em; font-family: "Times New Roman";\">1\u003C\u002Fspan>\u003Cspan style=\"font-family: "Times New Roman";\">). In opposite, \u003C\u002Fspan>\u003Cspan style=\"box-sizing: inherit; font-family: "Times New Roman";\">BCP\u003C\u002Fspan>\u003Cspan style=\"font-family: "Times New Roman";\"> oxidation derivative, \u003C\u002Fspan>\u003Cspan style=\"box-sizing: inherit; font-family: "Times New Roman";\">BCPO\u003C\u002Fspan>\u003Cspan style=\"font-family: "Times New Roman";\">, does not exhibit \u003C\u002Fspan>\u003Cspan style=\"box-sizing: inherit; font-family: "Times New Roman";\">CB\u003C\u002Fspan>\u003Cspan style=\"font-family: "Times New Roman";\"> \u003C\u002Fspan>\u003Cspan style=\"box-sizing: inherit; line-height: 0; position: relative; vertical-align: baseline; bottom: -0.25em; font-family: "Times New Roman";\">1\u002F2\u003C\u002Fspan>\u003Cspan style=\"font-family: "Times New Roman";\"> binding, thus the mechanism of its action is not related to endocannabinoid system (\u003C\u002Fspan>\u003Cspan style=\"box-sizing: inherit; font-family: "Times New Roman";\">ECS\u003C\u002Fspan>\u003Cspan style=\"font-family: "Times New Roman";\">) machinery. It is known that \u003C\u002Fspan>\u003Cspan style=\"box-sizing: inherit; font-family: "Times New Roman";\">BCPO\u003C\u002Fspan>\u003Cspan style=\"font-family: "Times New Roman";\"> alters several key pathways for cancer development, such as mitogen‐activated protein kinase (\u003C\u002Fspan>\u003Cspan style=\"box-sizing: inherit; font-family: "Times New Roman";\">MAPK\u003C\u002Fspan>\u003Cspan style=\"font-family: "Times New Roman";\">), \u003C\u002Fspan>\u003Cspan style=\"box-sizing: inherit; font-family: "Times New Roman";\">PI\u003C\u002Fspan>\u003Cspan style=\"font-family: "Times New Roman";\">3K\u002F\u003C\u002Fspan>\u003Cspan style=\"box-sizing: inherit; font-family: "Times New Roman";\">AKT\u003C\u002Fspan>\u003Cspan style=\"font-family: "Times New Roman";\">\u002F\u003C\u002Fspan>\u003Cspan style=\"box-sizing: inherit; font-family: "Times New Roman";\">mTOR\u003C\u002Fspan>\u003Cspan style=\"font-family: "Times New Roman";\">\u002FS6K1 and \u003C\u002Fspan>\u003Cspan style=\"box-sizing: inherit; font-family: "Times New Roman";\">STAT\u003C\u002Fspan>\u003Cspan style=\"font-family: "Times New Roman";\">3 pathways\u003C\u002Fspan>\u003C\u002Fp>\u003Cp>\u003Cspan style=\"font-family: "Times New Roman"; font-size: 14px;\">BCPO, \u003C\u002Fspan>\u003Cspan style=\"font-family: "Times New Roman"; font-size: 14px;\">in which the \u003C\u002Fspan>\u003Cfont face=\"sans-serif\">\u003Cspan style=\"background: none rgb(255, 255, 255); font-size: 14px; font-family: "Times New Roman";\">alkene\u003C\u002Fspan>\u003C\u002Ffont>\u003Cspan style=\"font-family: "Times New Roman"; font-size: 14px;\"> group of caryophyllene has become an \u003C\u002Fspan>\u003Cfont face=\"sans-serif\">\u003Cspan style=\"background: none rgb(255, 255, 255); font-size: 14px; font-family: "Times New Roman";\">epoxide\u003C\u002Fspan>\u003C\u002Ffont>\u003Cspan style=\"font-family: "Times New Roman"; font-size: 14px;\">, is the component responsible for cannabis identification by \u003C\u002Fspan>\u003Cfont face=\"sans-serif\">\u003Cspan style=\"background: none rgb(255, 255, 255);\">\u003Cspan style=\"font-size: 14px; font-family: "Times New Roman";\">drug-sniffing dogs\u003C\u002Fspan>\u003Cspan style=\"font-size: 14px; font-family: "Times New Roman";\">.\u003C\u002Fspan>\u003C\u002Fspan>\u003C\u002Ffont>\u003Cspan style=\"font-family: Cambria, "Cambria Math", stixgeneral, "Times New Roman", Times, serif; font-size: 20px;\">\u003Cbr>\u003C\u002Fspan>\u003Cbr>\u003C\u002Fp>\u003Cp>\u003Cbr>\u003C\u002Fp>",null,[],1785925856188]